While Boeing's main competitor, Airbus, focuses on larger airplanes to win its share of a $2.6 trillion (USD) new aircraft market over the next 20 years, Boeing is focusing on smaller more efficient airplanes.
Boeing is designing a new extended version of the 747 but does not plan to make an aircraft with more than 500 seats which is still short of the 555 seats that can be put on the super jumbo jet, the A380.
While the A380 is designed for hub to hub service, Boeing is designing the fuel-efficient 787 which would be used to fly from destination cities to hubs using less fuel and making more trips than current airliners.